A novel label free device has been designed and developed to diagnose the presence of cancer in suspicious regions, based on determination of the hypoxia glycolysis in quantitative manner. Electrochemical signals produced due to cancer cell metabolism is the basis of our diagnostic procedure. Importantly, integrated biosensor on the needles, named Cancer Diagnostic Probe (CDP), is fabricated and tested in real-time manner on the suspicious cancerous regions before and during surgery in mice species as well as human patients with breast cancer tumors (in vivo). The domain of suspicious margins with a resolution of 3mm was detected. It can be applied as an alternative method for frozen section pathology during the surgery with faster and more precise efficiency.
The surgical navigation system is functionally similar to the navigation system that use in airplanes or even mobile phones, which can inform us the exact position. This device will display the exact position of the surgical instruments to surgeons while surgery, from patient's CT scan or MRI images by using its tracking system. Therefore, the surgeon can have accurate information about the position of his instrument during surgery and reach his predetermined goal according to a predetermined plan with minimal risks and complications. For instance, it fully removes the tumor, conducts a comprehensive biopsy, or avoids damaging healthy tissues around the tumor.
The advantages of using this system are summarized as follows:
1- More complete surgery (complete removal of the tumor) and therefore reduce the likelihood of recurrence of the disease
2- Increase surgical accuracy, protect healthy tissues and therefore reduce surgical side effects
3- Possibility of accurate surgery (sampling of small lesions)
4- Reduce hospitalization time and return to normal life due to less invasive surgery
5- Increase patient safety
SinaFlex is a robotic surgery system which can be used for performing abdominal surgery operations in an ergonomic posture for surgeon and also remotely through internet or other communication channels. This system has two main subsystems including a master robotic console at the surgeon's side and a slave robotic system at patient's side. The master robots receive the surgeon's hands movements and transmit them to the patient's side robots that mimic the surgeon's hand movements in a real-time manner. Simultaneously, the slave robots measure the robot and patient interaction forces/torques, including the pinch forces under instruments jaws and transmit them to the surgeon's side master robotic system.
As a result, all tool-tissue interaction forces are fed backed to the surgeon's hands. This system has the advantages of high accuracy and quality of surgery, less incision for patients and more ergonomic posture for surgeons.